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KMID : 0370219830270040289
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Yakhak Hoeji
1983 Volume.27 No. 4 p.289 ~ p.293
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Syntheses and Central Nervous Depressant Activity of Piperine Derivatives(III) N-Piperoyl Amino Acids
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이한구/Lee HK
임중기/이은방/우원식/Lim JK/Lee EB/Woo WS
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Abstract
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Twelve new N-piperoyl amino acids were synthesized by acylation of amino acids with piperoylchloride in order to develop the new central nervous depressants. Silylation of the carboxylic group of amino acids not only precluded side reactions but also facilitated acylation at room temperature without catalysts. The acute toxicity of all the synthesized compounds were lower than that of piperine itself, whereas they showed strong protective effect against the strychnine-induced mortality.
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